Is the linear no-threshold (LNT) model relevant for radiotherapy?

Initially considered as a kind of radiobiological law, the linear no-threshold (LNT) model, which by definition supports absence any threshold for cancer risk induction after irradiation, is nowadays more reasonably described pragmatic and prudent approach International Organizations. However, it remains today dogma in radiological protection. Actually, this model had been essentially developed protection general population against low, sometimes very doses irradiation. Radiation oncologists are dealing with totally different situation since they deliver, on purpose, high radiations or less limited volumes body patients, patients whom no other alternatives do exist to get rid their malignant tumors. Simultaneously, radiation inevitably give low even at distance from so-called target volumes. In such specific situation, what carcinogenicity these relevance LNT radiotherapy? Thus, paper addresses three critical questions: 1) acceptability delivered radiotherapy tumors? 2) real carcinogenic (very) volume? 3) clinical data, i.e. , number second primary cancers, accumulated than century, consistent model? conclusion, appears be poorly adapted locally dramatically overestimates, most cases, secondary radio-induced cancers. fine would promote radiophobia see some them turning away life-saving treatment.